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" observation of guanine radicals induced by ultrasoft X-ray irradiation around the K-edge regions of nitrogen and oxygenYokoya, Akinari; Akamatsu, Ken; Fujii, Kentaro; Ukai, Masatoshi*
International Journal of Radiation Biology, 80(11-12), p.833 - 839, 2004/12
Times Cited Count：8 Percentile：48.81(Biology)no abstracts in English
Yokoya, Akinari; Akamatsu, Ken; Fujii, Kentaro
Nuclear Instruments and Methods in Physics Research B, 199, p.366 - 369, 2003/01
Times Cited Count：3 Percentile：27.69(Instruments & Instrumentation)no abstracts in English
Pinak, M.
Journal of Molecular Structure; THEOCHEM, 583(1-3), p.189 - 197, 2002/04
The local structural and energetic impact of a mutagenic oxidative lesion 7,8-dihydro-8-oxoguanine (8-oxoG) on a DNA molecule was studied by the method of a molecular dynamics (MD) simulation. The molecule of 8-oxoG was inserted into central part of B-DNA 15-mer d(GCGTCCA'8-oxoG'GTCTACC)
replacing the native guanine. The 2-nanosecond MD simulations were performed with the AMBER 5.0 program code at the constant temperature of 310 K (
36.5ºC, temperature of human body) for the 8-oxoG lesioned and native DNA molecules. The broken hydrogen bonds resulting in locally collapsed B-DNA structure were observed at the lesion site. The adenine 21 on the complementary strand (separated from 8-oxoG by 1 base pair) is flipped-out of the DNA double helix. Its extrahelical position forms a hole that may favor docking of repair enzyme into DNA during repair process. A strong electrostatic repulsion between nucleotide with the 8-oxoG and neighboring nucleotides contributes to the observed instability of DNA at the lesion.
